CHICAGO -- Fred VanVleet scored 22 points on perfect shooting and No. 3 Wichita State beat Loyola of Chicago 88-74 on Wednesday night to remain the only unbeaten team in major college basketball. Wichita State and top-ranked Syracuse began the day as the last Division I schools with perfect records. But the Orange lost 62-59 to Boston College in overtime, and the Shockers used an 11-2 run early in the second half to help close out the Ramblers. Cleanthony Early scored 18 points as Wichita State became the 19th school to begin a season with 28 straight victories. VanVleet was 6 for 6 from the field and made each of his 10 free throws. The Shockers (28-0, 15-0) can clinch the Missouri Valley Conference title with a victory at home against Drake on Saturday night. Milton Doyle scored 18 points and Jeff White had 14 for Loyola (9-18, 4-11), which has lost three straight and six of seven. Devon Turk finished with 13 points. Boosted by a capacity crowd at cozy Gentile Arena, the Ramblers battled back each time the Shockers tried to pull away in their first visit to Loyolas campus on the north side of Chicago since a 79-77 win on Feb. 9, 1976. It was just the third visit by a top-5 team to the Ramblers current home, joining No. 2 Michigan State in 2000 and No. 5 Kansas State in 2010. But every time Wichita State got a little push from Loyola, it just went back to its versatile group of athletic big men. The Shockers had a 41-24 rebounding advantage and went 31 for 34 from the free throw line, compared to 11 of 14 for Loyola. Chadrack Lufile had consecutive three-point plays to help Wichita State open a 52-36 lead with 15:43 to go. When the Ramblers pulled within 11 with 5 1/2 minutes left, Early made two foul shots and a 3-pointer to reach 1,000 career points and run the advantage back out to 16. Darius Carter added 13 points for Wichita State, which can close out a perfect regular season with three more wins. After the visit by the Bulldogs, the Shockers travel to Bradley before returning home for a tricky little finale against Missouri State. Wichita State trailed the Bears by 18 at halftime on Jan. 11, then rallied for a 72-69 overtime win. Early made each of his first three shots and had eight points when he picked up his second foul with 8:24 left in the first half, sending the senior star to the bench. Wichita State extended its lead to 35-24 before the Ramblers began to take advantage of Earlys absence inside. White drove for a three-point play and Christian Thomas had a basket and free throw to help Loyola pull within five with 1:28 remaining. Carter responded with a strong layup on the other end and Matt OLeary missed two 3s for Loyola in the final 42 seconds, leaving the Shockers with a 39-32 lead at the break. 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Pinch-hitter Tommy Medica singled in the go-ahead run in the eighth inning and the Padres beat the Seattle Mariners 2-1 in their first home game since Gwynn died of cancer Monday. MILWAUKEE -- Jason Hammel threw a sinker early in counts to try to entice groundball outs against an aggressive lineup and mixed things up with a fastball in the low 90s. It was an overwhelming combination for the short-handed Milwaukee Brewers. Hammel had a season-high seven strikeouts and allowed three hits in seven scoreless innings, Starlin Castro hit two solo homers and the Chicago Cubs snapped a four-game losing streak with a 4-0 win Sunday. Hammel, one of the few bright spots in a dismal April for Chicago, made his impressive work sound easy afterward. He hasnt given up more than five hits in each of his five starts. "I featured a pretty good sinker down in the zone early to get a lot of ground balls and just attacked the zone," he said. "So, thats really all it was today." Hammel (4-1) didnt allow a hit until Carlos Gomez doubled down the left-field line with one out in the sixth. He then got into trouble after walking Scooter Gennett and making an errant pickoff throw to put runners at second and third. But the righty got a strikeout before Aramis Ramirez bounced out to end the threat. "Great, great job. Mixed all his pitches well. Stayed down," manager Rick Renteria said. Chicago improved to 8-16, the last team in the majors to get to eight victories. Chicago scored twice in the second on Castros first homer and Darwin Barneys RBI fielders choice with the bases loaded off Brewers starter Wily Peralta (3-1). Castros second shot in the eighth off reliever Brandon Kintzler barely cleared the wall in the left-field corner. Castro had his second career multi-homer game in nearly three weeks, having going deep twice April 8 against Pittsburgh. His second-inning homer also just cleared the wall 400 feet away in dead centre and evaded the leaping Gomezs outstretched glove. On the mound, Peralta pumped his right arm in front of his waist in frustration. He thought the Gold Glove-winning Gomez might have had a shot at robbing the homer. "Always," Peralta said. "When GoGo runs back, you think he haas a chance to make the catch.dddddddddddd" Gomez said he had the perfect timing, "but its not even close." He went 1 for 4 on his bobblehead day. Peralta, a right-hander with a 96-mph fastball had trouble spotting pitches in the second. Ramirez stepped on third for an out on Barneys grounder but his throw trying to get Nate Schierholtz at home bounced up the first-base line to allow the run to score. Despite not having his best command, Peralta still just gave up three runs on eight hits in seven innings. He struck out six. "If hes not going to be sharp and thats what he does, its pretty good," manager Ron Roenicke said. Having Ryan Braun and Jean Segura could have helped, but both Milwaukee stars missed the game with injuries. Braun sat with a slight chest muscle strain, while Segura had a partially closed right eye and bruised right cheek after being accidentally hit during a practice swing by Braun on Saturday. Segura said after the game he hoped to return this week during the Brewers seven-game road trip to St. Louis and Cincinnati. Braun might miss three to five days. The remaining Brewers were overmatched by Hammel, who stayed low and away from the Brewers remaining potent right-handed bats. Hammel was lifted after allowing pinch hitter Rickie Weeks single to lead off the bottom of the eighth. Pedro Strop and Hector Rondon held the Brewers hitless the final two innings. Notes: Despite the win, the Cubs lost the three-game series to the Brewers and extended the teams string of winless series to 13 dating to last season. Chicago last won a series after taking two of three from Cincinnati in September. ... C John Baker went 2 for 4 that ended an 0-for-18 stretch. ... Ron Roenicke said the club would hold off on making any roster moves while Braun and Segura continue to be evaluated. ... The Brewers travel to St. Louis to start a seven-game road trip, with Yovani Gallardo (2-0) getting the start Monday. Chicago begins a three-game set in Cincinnati and sends Jeff Samardzija (0-2) to the mound. ' ' '